1372697-26-1

Basic information

• Product Name: methyl 5-(3-formylphenyl)-3-chlorothiophene-2-carboxylate
• Synonyms: methyl 5-(3-formylphenyl)-3-chlorothiophene-2-carboxylate
• CAS NO: 1372697-26-1
• Molecular Weight: 280.732
• Mol File: 1372697-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-(3-formylphenyl)-3-chlorothiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(3-formylphenyl)-3-chlorothiophene-2-carboxylate(1372697-26-1)
• EPA Substance Registry System: methyl 5-(3-formylphenyl)-3-chlorothiophene-2-carboxylate(1372697-26-1)

Safety Data

• Hazardous Substances Data: 1372697-26-1(Hazardous Substances Data)

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 88105-17-3 3-chlorothiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: Simple access to the less accessible regioisomers

The use of esters as blocking groups at the C2 position on a range of 3-substituted 5-membered ring heteroaromatics such as thiophenes or furans, allows control of the regioselectivity for the palladium-catalysed direct arylation at C5-H. This arylation can be followed by easy decarboxylation. This method allows sequential catalytic C5 arylation, decarboxylation and catalytic C2 arylation reactions.