88105-17-3

Basic information

• Product Name: METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE
• Synonyms: 3-chlorothiophene-2-carboxylate;3-CHLOROTHIOPHENE-2-CARBOXYLA;Methyl 3-chlorothiophene-2-carboxylate ,97%;RARECHEM AL BF 1228;3-CHLOROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;AKOS 90172;BUTTPARK 37\08-38;METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE
• CAS NO: 88105-17-3
• Molecular Formula: C₆H₅ClO₂S
• Molecular Weight: 176.62
• Product Categories: Esters;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 88105-17-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 37-38°C
• Boiling Point: 72-74°C 0,2mm
• Flash Point: 72-74°C/0.2mm
• Appearance: /
• Density: 1.28
• Vapor Pressure: 0.0411mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE(88105-17-3)
• EPA Substance Registry System: METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE(88105-17-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• TSCA: N
• Hazardous Substances Data: 88105-17-3(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystal powder

InChI:InChI=1/C6H5ClO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,1H3

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 67-56-1 methanol 
• 59337-89-2 3-chlorothiophene-2-carboxylic acid 

Downstream Products

• 59337-89-2 3-chlorothiophene-2-carboxylic acid 
• 1372697-13-6 methyl 3-chloro-5-(4-chlorophenyl)-thiophene-2-carboxylate 
• 1372697-21-6 methyl 3-chloro-5-(4-methoxyphenyl)-thiophene-2-carboxylate 
• 1372697-26-1 methyl 5-(3-formylphenyl)-3-chlorothiophene-2-carboxylate 
• 1372697-24-9 methyl 5-(3-cyanophenyl)-3-chlorothiophene-2-carboxylate 
• 1372697-18-1 methyl 5-(4-(tert-butyl)phenyl)-3-chlorothiophene-2-carboxylate 
• 1372697-15-8 methyl 3-chloro-5-(4-methylphenyl)-thiophene-2-carboxylate 
• 1372697-05-6 methyl 3-chloro-5-(4-cyanophenyl)-thiophene-2-carboxylate 
• 1372697-74-9 4-(4-chlorothiophen-2-yl)-benzonitrile 
• 1372697-36-3 methyl 5-(2-cyanophenyl)-3-chlorothiophene-2-carboxylate 
• 1372697-31-8 methyl 5-(3-nitrophenyl)-3-chlorothiophene-2-carboxylate 
• 1372697-09-0 methyl 3-chloro-5-(4-methoxycarbonylphenyl)-thiophene-2-carboxylate 
• 1372697-07-8 methyl 3-chloro-5-(4-acetylphenyl)-thiophene-2-carboxylate 
• 1372697-80-7 methyl 3-chloro-5-(4-formylphenyl)-thiophene-2-carboxylate 

Relevant articles and documents

SUBSTITUENT EFFECTS IN THIOPHENE COMPOUNDS. I. 1H NMR AND IR STUDIES IN METHYL (SUBSTITUTED 2-THIOPHENECARBOXYLATE)S.

The **1H NMR spectra and the IR carbonyl stretching frequencies of methyl (3-, 4-, and 5-substituted 2-thiophenecarboxylate)s have been reported. Good linear correlations between the chemical shifts of the ring protons in methyl (4- and 5-substituted 2-thiophenecarboxylate)s and those of the corresponding protons in substituted thiophenes were observed. The coupling constants in methyl (substituted 2-thiophenecarboxylate)s gave good correlations against the corresponding ones in substituted thiophenes. The IR carbonyl stretching frequencies in methyl (5-substituted 2-thiophenecarboxylate)s were correlated reasonably well with the chemical shifts of 5-protons in 2-substituted thiophenes. The coupling constants in methyl 2-thiophenecarboxylate series were found to very linearly with the electronegativities of the substituents.

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Tri- and tetracyclic heteroaromatic systems: Synthesis of novel benzo-, benzothieno- and thienofused pyrano[2,3-c]pyrazol-4(1H)-ones

A straightforward, two-step synthesis of chromeno[2,3-c]pyrazol-4(1H)-ones, thieno[2′,3′:5,6]pyrano[2,3-c]pyrazol-4(1H)-ones, and [1]benzo-thieno[2′,3′:5,6]pyrano[2,3-c]pyrazol-4(1H)-ones, respectively, is presented. Hence, treatment of 1-substituted or 1