1372697-82-9

Basic information

• Product Name: 4-(4-chlorothiophen-2-yl)-benzaldehyde
• Synonyms: 4-(4-chlorothiophen-2-yl)-benzaldehyde
• CAS NO: 1372697-82-9
• Molecular Weight: 222.695
• Mol File: 1372697-82-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-chlorothiophen-2-yl)-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorothiophen-2-yl)-benzaldehyde(1372697-82-9)
• EPA Substance Registry System: 4-(4-chlorothiophen-2-yl)-benzaldehyde(1372697-82-9)

Safety Data

• Hazardous Substances Data: 1372697-82-9(Hazardous Substances Data)

Upstream product

• 1372697-80-7 methyl 3-chloro-5-(4-formylphenyl)-thiophene-2-carboxylate 
• 1122-91-4 4-bromo-benzaldehyde 
• 88105-17-3 3-chlorothiophene-2-carboxylic acid methyl ester 

Downstream Products

• 1372697-84-1 methyl 4-[3-chloro-5-(4-formylphenyl)thiophen-2-yl]-benzoate 

Relevant articles and documents

Palladium-catalyzed selective decarboxylative coupling reaction versus direct C - H arylation for arylation of heteroaromatics

Conditions for selective palladium-catalyzed decarboxylative 2-arylation of 3-substituted thiophene and furan derivatives bearing an ester at C2 position have been established. By using 2 mol% phosphine-free Pd(OAc)2 as the catalyst and a mixture of KOH and K2CO3 as the bases, in dimethylacetamide, moderate to good yields of the desired 2-arylated products were obtained. A range of functional groups such as nitrile, nitro, formyl or acetyl on the aryl bromides was tolerated. This method allows us to employ in some cases more convenient reactants in terms of cost or physical properties (boiling point) for arylations. Copyright