1372702-72-1Relevant articles and documents
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production
Pham, Tuan-Ahn. N.,Che, Haiyan,Phan, Phuong-Thuy T.,Lee, Jae-Won,Kim, Sung-Soo,Park, Haeil
, p. 2534 - 2535 (2012)
A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2′-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC50 = 4.73 μM) than that of wogonin (IC50 = 7.80 μM).