Bioorganic and Medicinal Chemistry Letters p. 2534 - 2535 (2012)
Update date:2022-09-26
Topics:
Pham, Tuan-Ahn. N.
Che, Haiyan
Phan, Phuong-Thuy T.
Lee, Jae-Won
Kim, Sung-Soo
Park, Haeil
A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2′-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC50 = 4.73 μM) than that of wogonin (IC50 = 7.80 μM).
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