1373169-79-9Relevant academic research and scientific papers
Metal-Free Oxidative Annulation/Cyclization of 1,6-Enynes for the Synthesis of 4-Carbonylquinolines
Xia, Xiao-Feng,He, Wei,Wang, Dawei
supporting information, p. 2959 - 2964 (2019/04/30)
Herein we report on the development of a metal-free oxidative annulation reaction of 1,6-enynes, leading to 4-carbonylquinolines by using dioxygen as a green sustainable oxidant. Key advances include the use of readily available tert-butyl nitrite (TBN) to promote radical annulation of 1,6-enynes and easy-to-handle reaction conditions. Preliminary mechanistic studies including radical capture reactions and isotope labelling experiments are also conducted. (Figure presented.).
Visible-Light Induced and Oxygen-Promoted Oxidative Cyclization of Aromatic Enamines for the Synthesis of Quinolines Derivatives
Xia, Xiao-Feng,Zhang, Guo-Wei,Wang, Dawei,Zhu, Su-Li
, p. 8455 - 8463 (2017/08/23)
The dual transition metal-visible light photoredox catalysis for the synthesis of quinoline derivatives by using dioxygen as an oxygen source is developed. By using visible light, the direct oxidative cyclization of aromatic enamines with alkynes or alkenes can be achieved at mild conditions with an aid of copper or palladium catalysts, and a variety of multisubstituted quinoline derivatives could be obtained in good to moderate yields under mild reaction conditions.
Copper-catalyzed oxidative cyclization of enynes for the synthesis of 4-carbonyl-quinolines with O2
Xia, Xiao-Feng,Zhang, Lu-Lu,Song, Xian-Rong,Liu, Xue-Yuan,Liang, Yong-Min
, p. 2480 - 2483 (2012/07/13)
A novel copper-catalyzed oxidative cyclization of enynes and in situ formed enynes leading to 4-carbonyl-quinolines by using dioxygen as an oxygen source has been developed.
Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
Toh, Kah Kah,Sanjaya, Stephen,Sahnoun, Sophian,Chong, Sin Yee,Chiba, Shunsuke
, p. 2290 - 2292 (2012/06/30)
A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidine
