1373169-81-3

Basic information

• Product Name: ethyl 4-(4-chlorobenzoyl)-2-phenylquinoline-3-carboxylate
• Synonyms: ethyl 4-(4-chlorobenzoyl)-2-phenylquinoline-3-carboxylate
• CAS NO: 1373169-81-3
• Molecular Weight: 415.876
• Mol File: 1373169-81-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 4-(4-chlorobenzoyl)-2-phenylquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(4-chlorobenzoyl)-2-phenylquinoline-3-carboxylate(1373169-81-3)
• EPA Substance Registry System: ethyl 4-(4-chlorobenzoyl)-2-phenylquinoline-3-carboxylate(1373169-81-3)

Safety Data

• Hazardous Substances Data: 1373169-81-3(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 221910-19-6 2-(4-chlorophenylethynyl)phenylamine 
• 1374309-65-5 C₂₅H₂₀ClNO₂ 
• 615-43-0 2-iodophenylamine 
• 1373169-63-1 (Z)-ethyl 3-(2-((4-chlorophenyl)ethynyl)phenylamino)-3-phenylacrylate 
• 1373169-39-1 (Z)-ethyl 3-(2-ethynylphenylamino)-3-phenylacrylate 
• 1373169-38-0 (Z)-ethyl 3-phenyl-3-(2-((trimethylsilyl)ethynyl)phenylamino)acrylate 

Relevant articles and documents

Metal-Free Oxidative Annulation/Cyclization of 1,6-Enynes for the Synthesis of 4-Carbonylquinolines

Herein we report on the development of a metal-free oxidative annulation reaction of 1,6-enynes, leading to 4-carbonylquinolines by using dioxygen as a green sustainable oxidant. Key advances include the use of readily available tert-butyl nitrite (TBN) to promote radical annulation of 1,6-enynes and easy-to-handle reaction conditions. Preliminary mechanistic studies including radical capture reactions and isotope labelling experiments are also conducted. (Figure presented.).

Copper-catalyzed oxidative cyclization of enynes for the synthesis of 4-carbonyl-quinolines with O2

A novel copper-catalyzed oxidative cyclization of enynes and in situ formed enynes leading to 4-carbonyl-quinolines by using dioxygen as an oxygen source has been developed.