1373247-35-8

Upstream product

• 1373247-33-6 (3S,4R)-benzyl 3-(3-methoxy-3-oxopropyl)-4-(3-methoxyphenyl)-2-oxotetrahydrofuran-3-carboxylate 
• 1373247-32-5 (3R,4S)-benzyl 4-(3-methoxyphenyl)-2-oxotetrahydrofuran-3-carboxylate 
• 7706-85-6 4-(3-methoxyphenyl)furan-2(5H)-one 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 

Downstream Products

• 1373247-37-0 (5S,9R)-9-(2,4-dibromo-5-methoxyphenyl)-7-oxa-1-azaspiro[4.4]nonane-2,6-dione 
• 1373247-25-6 (5S,9R)-9-(2,4-dibromo-5-methoxyphenyl)-7-methyl-1,7-diazaspiro[4.4]nonane-2,6,8-trione 
• 1373247-39-2 C₁₅H₁₆Br₂N₂O₄ 

Relevant academic research and scientific papers

Antiproliferative activity of amathaspiramide alkaloids and analogs

Assisted by the total syntheses of all the amathaspiramides, six natural products and four synthetic intermediates with partially fluctuating structures were prepared and subjected to a growth inhibition assay in four human cancer cell lines. The results

Total syntheses of all the amathaspiramides

Six in one blow: Total syntheses of all the amathaspiramide alkaloids have been accomplished. Rapid construction of the diazaspiro[3.3]nonane core combined with regio- and diastereoselective reduction of the cyclic imide moiety with DIBAL established the route to the common structural motif. The late-stage reduction of the lactam to an imine functionality mediated by Schwartz's reagent was the key to the streamlined syntheses. Copyright