1373311-92-2

Upstream product

• 1373311-90-0 N-tert-butoxycarbonyl-L-3-iodotyrosyl-L-3-iodotyrosine methyl ester 
• 1373311-91-1 cyclodi(L-3-iodotyrosine) 
• 100-39-0 benzyl bromide 
• 1080-06-4 L-Tyr-OMe 
• 60-18-4 L-tyrosine 
• 79677-58-0 2-amino-3-(3-iodo-4-hydroxyphenyl)propionic acid methyl ester hydrochloride 
• 71400-63-0 N-tert-butyloxycarbonyl-3-iodo-L-tyrosine 
• 27513-48-0 N-(tert-butoxycarbonyl)-L-tyrosyl-L-tyrosine methyl ester 
• 374674-80-3 (3S,6S)-3,6-bis(p-(benzyloxy)benzyl)piperazine-2,5-dione 
• 10125-11-8 cis-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione 
• 218769-48-3 (S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 71400-64-1 (S)-methyl 2-amino-3-(4-(benzyloxy)-3-iodophenyl)propanoate hydrochloride 
• 691394-91-9 methyl (S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoate 
• 119336-08-2 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3-iodophenyl)propanoate 

Downstream Products

• 1373311-93-3 (4²S,4⁵S)-1⁶,2⁶-bis(benzyloxy)-4(2,5)-piperazina-1,2(1,3)-dibenzenacyclopentaphane-4³,46-dione 

Relevant academic research and scientific papers

Scalable Synthesis of Mycocyclosin

We report herein the scalable total synthesis of the secondary metabolite, mycocyclosin, initially isolated from Mycobacterium tuberculosis. Mycocylosin bears a highly strained 3,3′-dityrosine biaryl system which arises biosynthetically from an intramolec

Total synthesis of mycocyclosin

The first total synthesis of mycocyclosin, a diketopiperazine natural product isolated from M. tuberculosis, is described. While direct oxidative coupling of tyrosine phenolic groups was unsuccessful, construction of the highly strained bicyclic framework was successfully accomplished through an intramolecular Miyaura-Suzuki cross-coupling to generate the biaryl linkage.