137332-55-9 Usage
Uses
Used in Pharmaceutical Industry:
(5S)-8-fluoro-5-methyl-6-(3-methylbut-2-en-1-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione is used as a potential pharmaceutical agent for its sedative and anxiety-reducing properties, which are characteristic of benzodiazepines. The specific structural features of (5S)-8-fluoro-5-methyl-6-(3-methylbut-2-en-1-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione may offer advantages over traditional benzodiazepines, such as improved efficacy, reduced side effects, or a more targeted therapeutic profile.
Used in Research and Development:
(5S)-8-fluoro-5-methyl-6-(3-methylbut-2-en-1-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione is also used in the research and development of new drugs, particularly in the field of medicinal chemistry. Its unique structure and potential pharmacological properties make it an interesting candidate for further study, with the aim of developing novel therapeutic agents for various medical conditions.
Used in Drug Design and Optimization:
(5S)-8-fluoro-5-methyl-6-(3-methylbut-2-en-1-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione's structural features, including the fluoro group and the 6-(3-methylbut-2-en-1-yl) side chain, make it a valuable tool in drug design and optimization. Researchers can use (5S)-8-fluoro-5-methyl-6-(3-methylbut-2-en-1-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione as a starting point to create new drugs with improved properties, such as increased potency, better selectivity, or reduced toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 137332-55-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,3,3 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 137332-55:
(8*1)+(7*3)+(6*7)+(5*3)+(4*3)+(3*2)+(2*5)+(1*5)=119
119 % 10 = 9
So 137332-55-9 is a valid CAS Registry Number.
137332-55-9Relevant academic research and scientific papers
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5- methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 4
Ho,Kukla,Breslin,Ludovici,Grous,Diamond,Miranda,Rodgers,Ho,De Clercq,Pauwels,Andries,Janssen,Janssen
, p. 794 - 802 (2007/10/02)
In previous papers, we have described the discovery of a new series of compounds, 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-ones, TIBO (1 and 1a), with potent anti-HIV-1 activity and the synthesis of analogues to better define
Process for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2(1H)-thiones
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, (2008/06/13)
Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thiones of formula STR1 starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) STR2 Novel enantiomerically pure inter
Regioselectivity in Intramolecular Nucleophilic Aromatic Substitution. Synthesis of the Potent Anti HIV-1 8-Halo TIBO Analogues
Parker, Kathlyn A.,Coburn, Craig A.
, p. 97 - 100 (2007/10/02)
Regioselective intramolecular nucleophilic substitution of 2,6-dihalo-3-nitrobenzyl diamines 2b and 2c gave benzodiazepines 3.These intermediates are useful in the preparation of the 8-halo TIBO derivatives 1, inhibitors of HIV-I replication in cell cultu
