1373344-36-5

Upstream product

• 20007-99-2 Wieland-Miescher ketone 
• 878-47-7 (4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one 
• 39085-59-1 trisylhydrazine 
• 1373344-41-2 (2S,4aR,8aS)-2-methoxy-4a-methyloctahydrochromen-5-one 
• 1373344-38-7 3-((1R,6S)-1-methyl-2-oxo-6-((triethylsilyl)oxy)cyclohexyl)propanoic acid 
• 1373344-35-4 (4aS,5S)-4a-methyl-5-((triethylsilyl)oxy)-4,4,5,6,7,8-hexahydronaphthalen-2(3H)-one 

Downstream Products

• 1373344-43-4 (2S,4aS,8aS)-2-methoxy-4a-methyl-3,4,4a,7,8,8a-hexahydro-2H-chromene 
• 1373344-42-3 1-((2S,4aS,8aS)-2-methoxy-4a-methyl-3,4,4a,7,8,8a-hexahydro-2H-chromen-5-yl)-3-phenylpropan-1-ol 

Relevant academic research and scientific papers

Study of Cascade Ring-Closing Metathesis Reactions en Route to an Advanced Intermediate of Taxol

A highly functionalized intermediate in the synthesis of Taxol has been synthesized, which features the tricyclic core and the required oxygen substituents at C1, C2, C7, C10, and C13. The key step, a ring-closing dienyne metathesis (RCDEYM) reaction, has

Enantioselective synthesis of a taxol C ring

An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful.