1373399-87-1Relevant academic research and scientific papers
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2] octane skeleton and their pharmacologies
Watanabe, Yoshikazu,Kitazawa, Shota,Fujii, Hideaki,Nemoto, Toru,Hirayama, Shigeto,Nagase, Hiroshi
, p. 2689 - 2692 (2012/05/20)
A novel opioid ligand possessing a stable and cyclic imine 16 and its derivatives with an azabicyclo[2.2.2]octane skeleton were synthesized. The imine 16 showed higher affinity for the μ receptor than compound 21 with an oxabicyclo[2.2.2]octane skeleton.
