1373401-69-4Relevant academic research and scientific papers
Conjugate addition of isocyanides to chromone 3-carboxylic acid: An efficient one-pot synthesis of chroman-4-one 2-carboxamides
Neo, Ana G.,Diaz, Jesus,Marcaccini, Stefano,Marcos, Carlos F.
experimental part, p. 3406 - 3416 (2012/05/20)
We report a novel Lewis acid catalysed tandem reaction of isocyanides, chromone 3-carboxylic acid and nucleophiles. An experimentally very simple procedure, involving the use of microwave irradiation in the presence of a Lewis acid catalyst, affords a representative collection of chromone-2-carboxamides and chromone-2-carboxamido-3-esters in high yields, in just a few minutes. Such an unprecedented strategy is formally equivalent to a conjugate addition of isocyanides to Michael acceptors.
