1373422-53-7 Usage
Uses
Used in Epigenetic Research:
GSK J1 is used as a research tool for studying the role of histone demethylases in epigenetic regulation. By inhibiting JMJD3 and UTX, it helps researchers understand the function of these enzymes in various biological processes and their potential as therapeutic targets.
Used in Drug Development:
GSK J1 serves as a starting point for the development of new drugs targeting histone demethylases, which may have applications in treating various diseases, including cancer and other conditions related to epigenetic dysregulation.
Used in In Vitro Assays:
Due to its cell impermeability, GSK J1 is used as a standard in in vitro assays to study the activity and specificity of histone demethylases. This helps researchers evaluate the effectiveness of potential inhibitors and their impact on cellular processes.
Used in the Development of Cell-Permeable Analogs:
GSK J1 has led to the development of a cell permeable ethyl ester analog, GSK J4, which may have potential applications in cellular studies and therapeutic interventions. This analog is designed to overcome the cell impermeability issue of GSK J1, allowing for more direct investigation of the effects of histone demethylase inhibition in cells.
Biochem/physiol Actions
GSK-J1 is also termed as 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate. It may disturb the differentiation of specific neuronal subtypes in growing rat retina.
References
1) Kruidenier et al. (2012), A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response; Nature, 488 404
Check Digit Verification of cas no
The CAS Registry Mumber 1373422-53-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,3,4,2 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1373422-53:
(9*1)+(8*3)+(7*7)+(6*3)+(5*4)+(4*2)+(3*2)+(2*5)+(1*3)=147
147 % 10 = 7
So 1373422-53-7 is a valid CAS Registry Number.
1373422-53-7Relevant academic research and scientific papers
Immobilization products and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
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, (2013/05/23)
The present invention relates to immobilization products comprising compounds of formula (I) and preparations thereof as well as methods and uses for the identification of histone demethylase interacting compounds or for the purification or identification of histone demethylase proteins.
N-2-(2-PYRIDINYL)-4-PYRIMIDINYL-BETA-ALANINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE JMJD3
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Page/Page column 110, (2012/05/05)
A method of treating autoimmune diseases or conditions in a mammal, such as a human, which comprises the administration of a therapeutically effective amount of histone demethylase enzymes of formula (I).
