1373429-31-2Relevant academic research and scientific papers
RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists
Kakuta, Hiroki,Yakushiji, Nobumasa,Shinozaki, Ryosuke,Ohsawa, Fuminori,Yamada, Shoya,Ohta, Yui,Kawata, Kohei,Nakayama, Mariko,Hagaya, Manabu,Fujiwara, Chisa,Makishima, Makoto,Uno, Shigeyuki,Tai, Akihiro,Maehara, Ami,Nakayama, Masaru,Oohashi, Toshitaka,Yasui, Hiroyuki,Yoshikawa, Yutaka
, p. 427 - 432 (2012/06/30)
Treating insulin resistance and type 2 diabetes in rodents, currently known retinoid X receptor (RXR) agonists induce significant adverse effects. Here we introduce a novel RXR partial agonist CBt-PMN (11b), which shows a potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists. We suggest that RXR partial agonists may be a new class of antitype 2 diabetes drug candidates.
