1373432-41-7Relevant academic research and scientific papers
Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions
Tang, Wenjun,Patel, Nitinchandra D.,Xu, Guangqing,Xu, Xiaobing,Savoie, Jolaine,Ma, Shengli,Hao, Ming-Hong,Keshipeddy, Santosh,Capacci, Andrew G.,Wei, Xudong,Zhang, Yongda,Gao, Joe J.,Li, Wenjie,Rodriguez, Sonia,Lu, Bruce Z.,Yee, Nathan K.,Senanayake, Chris H.
, p. 2258 - 2261 (2012)
A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki-Miyaura coupling reactions, enabling the construction of an array of chiral biaryl products in high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety in these chiral biaryl products allows facile derivatization for further synthetic applications. A computational study has revealed that a π-π interaction between the two coupling partners can enhance the enantioselectivity of the coupling reaction.
