1373493-14-1Relevant articles and documents
Nonsteroidal androgen receptor ligands: Versatile syntheses and biological data
Varchi, Greta,Guerrini, Andrea,Tesei, Anna,Brigliadori, Giovanni,Bertucci, Carlo,Di Donato, Marzia,Castoria, Gabriella
, p. 454 - 458 (2012/09/21)
We report herein a stereoselective and straightforward methodology for the synthesis of new androgen receptor ligands with (anti)-agonistic activities. Oxygen-nitrogen replacement in bicalutamide-like structures paves the way to the disclosure of a new class of analogues, including cyclized/nitrogen-substituted derivatives, with promising antiandrogen (or anabolic) activity.