1373493-82-3Relevant academic research and scientific papers
Friedel-Crafts amidoalkylation via thermolysis and oxidative photocatalysis
Dai, Chunhui,Meschini, Francesco,Narayanam, Jagan M. R.,Stephenson, Corey R. J.
, p. 4425 - 4431 (2012)
Friedel-Crafts amidoalkylation was achieved by oxidation of dialkylamides using persulfate (S2O82-) in the presence of the visible light catalyst, Ru(bpy)3Cl2, at room temperature, via a reactive N-acyliminium intermediate. Alternatively, mild heating of the dialkylamides and persulfate afforded a metal and Lewis acid-free Friedel-Crafts amidoalkylation. Alcohols and electron-rich arenes served as effective nucleophiles, forming new C-O or C-C bonds. In general, photocatalysis provided higher yields and better selectivities.
