1373494-42-8Relevant articles and documents
Ligand-free Pd-catalysed decarboxylative arylation of imidazo[1,2-: A] pyridine-3-carboxylic acids with aryl bromides
Karale, Uttam B.,Kalari, Saradhi,Shivakumar, Jala,Makane, Vitthal B.,Babar, Dattatraya A.,Thakare, Ritesh P.,Babu, Bathini Nagendra,Chopra, Sidharth,Rode, Haridas B.
, p. 65095 - 65104 (2016)
A facile ligand-free method for Pd(OAc)2 catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with hetero(aryl) bromides has been developed. This method is applicable to a variety of (hetero)aryl bromides as coupling partners. Electron withdrawing and donating groups on imidazo[1,2-a]pyridine-3-carboxylic acids are well tolerated. It represents the first general protocol for ligand-free Pd(OAc)2 catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with (hetero)aryl halides. A few of the compounds synthesized using this protocol showed antibacterial activity against Staphylococcus aureus.
Phosphine-free palladium-catalyzed direct arylation of imidazo[1,2-a] pyridines with aryl bromides at low catalyst loading
Fu, Hai Yan,Chen, Lu,Doucet, Henri
experimental part, p. 4473 - 4478 (2012/06/30)
Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of imidazo[1,2-a]pyridines at C3 under very low catalyst concentration. The reaction can be performed employing as little as 0.1-0.01 mol % catalyst with electron-
