1373494-46-2

Upstream product

• 274-76-0 imidazo[1,2-a]pyridine 
• 6952-59-6 3-cyanobromobenzene 
• 69113-59-3 3-iodobenzonitrile 
• 109-04-6 2-bromo-pyridine 
• 274-87-3 tetrazolo[1,5-a]pyridine 
• 171290-53-2 3-ethynylbenzonitrile 
• 1235553-97-5 naphthalen-2-yl 4-methylbenzene-1-sulfonate 
• 49584-07-8 3-cyanophenyl-4-methylbenzene-1-sulfonate 

Relevant academic research and scientific papers

Cobalt-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridine with Aryl Iodides

The Co(II)Cl2·6H2O catalyzed C–H activation/direct arylation of imidazo[1,2-a]pyridine with aryl/heteroaryl iodide is reported. The cost effective, ligand and additive free protocol using KOAc successfully afforded 3-arylimidazo[1,2-

Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

Regioselective direct c-3 arylation of imidazo[1,2- a ]pyridines with aryl tosylates and mesylates promoted by palladium-phosphine complexes

Direct C-3 arylation of imidazo[1,2-a]pyridines with aryl tosylates and mesylates has been accomplished by employing palladium(II) acetate associated with SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) or L1 (2-(2-(diisopropylphosphino)phenyl)-1-methyl-1H-indole). This catalyst system can be applied to a wide range of aryl sulfonates and shows excellent C-3 regioselectivity of imidazo[1,2-a]pyridine. These results represent the first examples of using tosylate- and mesylate-functionalized arenes as the electrophile partners for this regioselective direct arylation.

Direct catalytic C-H arylation of imidazo[1,2-a]pyridine with aryl bromides using magnetically recyclable Pd-Fe3O4 nanoparticles

The direct C-H arylation of a heteroarene with aryl bromides has been achieved under the catalysis of magnetic nanoparticles. In the presence of bimetallic Pd-Fe3O4 heterodimer nanocrystals (1 mol % in palladium), the reaction of imi

Phosphine-free palladium-catalyzed direct arylation of imidazo[1,2-a] pyridines with aryl bromides at low catalyst loading

Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of imidazo[1,2-a]pyridines at C3 under very low catalyst concentration. The reaction can be performed employing as little as 0.1-0.01 mol % catalyst with electron-