1373497-79-0

Upstream product

• 88-15-3 2-Acetylthiophene 
• 3328-73-2 4-hydroxy-5-methylisophthalaldehyde 
• 95-48-7 ortho-cresol 

Downstream Products

• 1373497-75-6 (E)-3-(3,4-dimethoxyphenyl)-8-methyl-6-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)-2H-chromen-2-one 
• 1375171-21-3 (E)-6-((2-(7-chloroquinolin-4-ylamino)ethylamino)methylene)-2-methyl-4-((E)-3-oxo-3-(thiophen-2-yl)prop-1-enyl)cyclohexa-2,4-dienone 
• 1616108-77-0 (E)-1-(furan-2-yl)-3-(4-hydroxy-3-methyl-5-((E)-(thiazol-2-ylimino)methyl)phenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents

DNA replication and repair are complex processes accomplished by the concerted action of a network of enzymes and proteins. DNA ligases play a crucial role in these processes by catalyzing the nick joining between DNA strands. As compared to normal cells,

Highly efficient synthesis of chalcones from poly carbonyl aromatic compounds using bf3-et2o via a regioselective condensation reaction

A new, simple, highly efficient method for the synthesis of different types of carbonyl chalcones through a regioselective condensation reaction of appropriate 5-acetyl-2-hydroxybenzaldehyde with various substituted acetophenones and 4-hydroxyisothalaldehyde with various substituted aldehydes using BF3-Et2O as a reagent is described.

Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi

Here we report the synthesis of novel chalcone-thiazole compounds and their antifilarial activity. The antifilarial properties of these hybrids were assessed against microfilariae as well as adult worms of Brugia malayi. Among all the synthesized compound

Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores

A series of novel keto-enamine chalcone-chloroquine based hybrids were synthesized following new methodology developed in our laboratory. The synthesized compounds were screened against chloroquine sensitive strain (3D7) of Plasmodium falciparum in an in

Efficient and general synthesis of 3-aryl coumarins using cyanuric chloride 1

An efficient and general protocol for a rapid synthesis of different substituted 3-aryl coumarins is reported. A series of different substituted phenyl acetic acids have been successfully reacted with different substituted 2-hydroxy benzaldehydes in the presence of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and N-methyl morpholine to afford 3-aryl coumarins in good to excellent yields. Georg Thieme Verlag Stuttgart · New York.