137351-38-3

Upstream product

• 67655-17-8 α-chloro-α-(phenylthio)acetophenone 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 
• 882-33-7 diphenyldisulfane 
• 873-55-2 sodium benzenesulfonate 
• 536-74-3 phenylacetylene 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 22183-12-6 (E)-1-((2-iodo-2-phenylvinyl)sulfonyl)-4-methylbenzene 

Relevant academic research and scientific papers

Unprecedented Reactivity of β-Iodovinyl Sulfones: An Efficient Synthesis of β-Keto Sulfones and β-Keto Thiosulfones

An unprecedented reactivity of (E)-β-iodovinyl sulfones in the presence of NaOAc is reported. The (E)-β-iodovinyl sulfones were treated with NaOAc in DMSO/H2O to yield β-keto sulfones in moderate to high yields. A novel oxidative difunctionalization of β-iodovinyl sulfones with thiosulfonates and NaOAc in DMF has been developed. This metal-free oxosulfenylation is an operationally simple to access a wide range of β-keto thiosulfones (α-thioaryl-β-keto sulfones) in moderate to high yields. The transformations were reliable at gram-scale, thus illustrating its efficiency and practicality. A plausible mechanism for the protocol is also proposed.

Mono halogenation of β-keto sulfides. Synthesis of β-keto-α-phenylthio p-tolyl sulfones

β-Keto-α-phenylthio p-Tolyl sulfones are obtained from β-keto-alkyl phenyl sulfides by halogenation with NCS followed by treatment with sodium p-toluene sulphinate.