1373610-96-8

Basic information

• Product Name: 1-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)pyrrolidine
• CAS NO: 1373610-96-8
• Molecular Weight: 349.396
• Mol File: 1373610-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)pyrrolidine(1373610-96-8)
• EPA Substance Registry System: 1-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)pyrrolidine(1373610-96-8)

Safety Data

• Hazardous Substances Data: 1373610-96-8(Hazardous Substances Data)

Upstream product

• 62872-58-6 3-iodo-1-phenyl-propan-1-ol 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 936-59-4 3-chloropropiophenone 
• 4641-67-2 1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol 
• 98-56-6 4-chlorobenzotrifluoride 

Relevant articles and documents

Simplified heterocyclic analogues of fluoxetine inhibit inducible nitric oxide production in lipopolysaccharide-induced BV2 cells

A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells. Although the synthesized compounds generally revealed weaker activity or greater cytotoxicity than fluoxetine, compound 10a, in which the N-methylamino group in fluoxetine was replaced by morpholine, and the trifluoromethylphenyl ring was substituted with simple oxo group, suppressed NO production dose-dependently at 10, 20 and 40 μM concentrations with less cytotoxicity than fluoxetine, and inhibited iNOS mRNA and protein expression at the same concentrations in LPS-induced BV2 cells. The results suggested that the trifluoromethylphenyl ring moiety in fluoxetine is not necessary for the suppression of NO production and that 10a has the potential as a potent inhibitor of NO production.