4641-67-2

Usage

Class

Secondary amine, Alcohol

Structure

Contains a phenyl group attached to a pyrrolidin-1-yl group, which is attached to a propan-1-ol group.

Usage

Organic synthesis, pharmaceutical research (building block for the synthesis of various drugs and pharmaceutical compounds)

Potential applications

Medicinal chemistry, drug discovery (due to unique chemical structure and properties)

Upstream product

• 94-39-3 1-phenyl-3-(pyrrolidin-1-yl)propan-1-one 
• 98-86-2 acetophenone 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 936-59-4 3-chloropropiophenone 
• 123-75-1 pyrrolidine 
• 62872-58-6 3-iodo-1-phenyl-propan-1-ol 

Downstream Products

• 157846-67-8 Methanesulfonic acid 1-phenyl-3-pyrrolidin-1-yl-propyl ester 
• 42796-29-2 1-(3-Phenoxy-3-phenyl-propyl)-pyrrolidine 
• 157846-77-0 1-[3-(3-Methoxy-phenoxy)-3-phenyl-propyl]-pyrrolidine 
• 157846-78-1 1-[3-(4-Methoxy-phenoxy)-3-phenyl-propyl]-pyrrolidine 
• 157846-76-9 1-[3-(2-Methoxy-phenoxy)-3-phenyl-propyl]-pyrrolidine 
• 157846-79-2 1-[3-(3,4-Dimethoxy-phenoxy)-3-phenyl-propyl]-pyrrolidine 
• 1373610-96-8 1-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)pyrrolidine 
• 1384515-30-3 2-phenylhexahydro-2H-pyrrolo[2,1-b][1,3]oxazine 

Relevant academic research and scientific papers

Electrooxidative cyclization of hydroxyamino compounds possessing a benzyl group

Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2- piperidinemethanols, respectively, by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base. Georg Thieme Verlag Stuttgart · New York.

Simplified heterocyclic analogues of fluoxetine inhibit inducible nitric oxide production in lipopolysaccharide-induced BV2 cells

A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells. Although the synthesized compounds generally revealed weaker activity or greater cytotoxicity than fluoxetine, compound 10a, in which the N-methylamino group in fluoxetine was replaced by morpholine, and the trifluoromethylphenyl ring was substituted with simple oxo group, suppressed NO production dose-dependently at 10, 20 and 40 μM concentrations with less cytotoxicity than fluoxetine, and inhibited iNOS mRNA and protein expression at the same concentrations in LPS-induced BV2 cells. The results suggested that the trifluoromethylphenyl ring moiety in fluoxetine is not necessary for the suppression of NO production and that 10a has the potential as a potent inhibitor of NO production.

Synthesis of 3-aryloxy-3-phenylpropanamines as possible antidepressants

Thirteen new 3-aryloxy-3-phenylpropanamines (11-23) have been prepared and their structures elucidated by mass, IR and 1H-NMR spectra and by elemental analysis.Being structurally similar to fluoxetine these compounds have been tested for their effect on g