1373613-92-3

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 501-53-1 benzyl chloroformate 
• 163116-18-5 N-ethoxycarbonylmethyl-β-alanine t-butyl ester 

Downstream Products

• 1373613-93-4 3-{N-benzyloxycarbonyl-N-(ethoxycarbonylmethyl)amino}propionic acid 
• 1373613-95-6 benzyl 3-(cyclopropylcarbamoyl)-4-oxopyrrolidine-1-carboxylate 
• 949495-13-0 benzyl (3S,4R)-3-(cyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate 
• 1373613-94-5 ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate 
• 949495-19-6 benzyl (3R,4S)-3-(cyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE

The present invention provides an inexpensive and industrially advantageous method for producing an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxypyrrolidine derivative or it's enantiomer, which is a key intermediate for producing a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or it's enantiomer useful as an intermediate for producing pharmaceuticals. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxypyrrolidine-3-carboxamide derivative, or it's enantiomer by carrying out asymmetric hydrogenation using an optically active catalyst of a 4-oxopyrrolidine-3-carboxamide derivative represented by the general formula (I). [in the formula (I), PG1 represents a protective group for an amino group, and R1 represents hydrogen, a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted].