137369-22-3

Upstream product

• 108-46-3 recorcinol 
• 2161-85-5 1-(5-acetyl-2,4-dihydroxyphenyl)-1-ethanone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 137369-28-9 2,3-Dibromo-1-{5-[2,3-dibromo-3-(4-methoxy-phenyl)-propionyl]-2,4-dihydroxy-phenyl}-3-(4-methoxy-phenyl)-propan-1-one 
• 137369-35-8 4,6-bis[5-(4-methoxyphenyl)-1,2-oxazol-3-yl]benzene-1,3-diol 
• 32140-78-6 3,7-dihydroxy-2,8-di(4-methoxyphenyl)-4H,6Hpyrano[3,2-g]chromene-4,6-dione 

Relevant academic research and scientific papers

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents

Chalcones have a distinctive 1,3-diarylpropenone skeleton and exert numerous biological effects. Using a one-step Claisen-Schmidt condensation, we synthesized eleven bis-chalcones (3-13) and three acetyl chalcones (14-16) from substituted aldehydes and diacetylresorcinol. The compounds were tested for in vitro cytotoxic activity against four human cancer cell lines (A549, DU145, KB, and KB-VIN) and inhibition of NO production in lipopolysaccharide (LPS)-activated microglial cells. Among them, four compounds (3, 5, 6, and 13) showed significant cytotoxic activity with EC50 values ranging from 1.57 to 5.14 μM, and seven compounds (3, 5-8, 10, and 13) displayed potent anti-inflammatory activity by inhibiting NO production with IC50 values ranging from 0.95 to 8.65 μM. A mechanism of action study of active compounds 6 and 7 discovered that these compounds down-regulated iNOS expression by inhibiting p65 NF-κB activation/nuclear translocation due to prevention of IκBα degradation. Structure-activity relationship (SAR) findings are also discussed.

A facile synthesis of 3,7-diphenyl-4,6-distyryl-2,8-dioxo-2h,8h- benzo(1,2-b:5,4-b')dipyrans and their antifeedant activity

The synthesis, characterisation and antifeedant activity of some new dicoumarins prepared from 4,6-diacetyl resorcinol has been reported.

Synthesis of 4,6-Bis(2'-substituted-2',3'-dihydro-1,5-benzothiazepin-4'-yl) resorcinols as potential antifeedants

4,6-Bis(2'-substituted-2',3'-dihydro-1,5-benzothiazepin-4'-yl) resorcinols (3a-j) have been prepared in one step by the reaction of dichalcones (2a-j) with 2-aminothiophenol in ethanol containing gl. acetic acid and their structures established by element