1373693-82-3

Upstream product

• 1373693-81-2 tert-butyl (1S)-1-(2-{[(2S)-1-methoxy-3-phenylpropan-2-yl]carbamoyl}-5-methylphenyl)hexyl carbonate 

Downstream Products

• 1191434-34-0 lorneic acid A 
• 1373693-83-4 (1S)-1-(2-{[(tert-butyldimethylsilyl)oxy]methyl}-5-methylphenyl)hexyl (2S)-2-methoxy-2-phenylacetate 
• 1373693-84-5 (1S)-1-(2-{[(tert-butyldimethylsilyl)oxy]methyl}-5-methylphenyl)hexyl (2R)-2-methoxy-2-phenylacetate 
• 1373693-85-6 (S,E)-methyl 3-(2-(1-hydroxyhexyl)-4-methylphenyl)acrylate 
• 1373693-86-7 (S,E)-methyl 3-(2-(1-(methoxymethoxy)hexyl)-4-methylphenyl)acrylate 
• 1373693-87-8 (S,E)-3-(2-(1-(methoxymethoxy)hexyl)-4-methylphenyl)prop-2-en-1-ol 
• 1373693-88-9 (S,E)-4-(2-(1-(methoxymethoxy)hexyl)-4-methylphenyl)but-3-enenitrile 
• 1373693-89-0 (S,E)-4-(2-(1-(methoxymethoxy)hexyl)-4-methylphenyl)but-3-enoic acid 
• 1192037-67-4 (-)-lorneic acid B 
• 1373693-90-3 (E)-methyl 3-(2-((E)-hex-1-enyl)-4-methylphenyl)acrylate 
• 1373693-91-4 (2E)-3-(2-((1E)-hex-1-enyl)-4-methylphenyl)prop-2-en-1-ol 
• 1373693-92-5 (3E)-4-(2-((1E)-hex-1-enyl)-4-methylphenyl)but-3-enenitrile 
• 1373693-95-8 (1S)-1-(2-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylphenyl)hexan-1-ol 

Relevant academic research and scientific papers

First syntheses of lorneic acids A and B with potential PDE5 inhibition activity

Two natural products with potential PDE5 inhibition activity, lorneic acids A and B, have been synthesized for the first time in high yield using a chiral amide stereocontrolled addition of aryl lithium to aldehyde as the key step, and the configuration of the chiral benzylic alcohol in lorneic acid B was determined to be S. Georg Thieme Verlag Stuttgart · New York.