137372-05-5Relevant academic research and scientific papers
Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs
Wang, Chao,Zhang, Tian-Tai,Du, Guan-Hua,Zhang, Dong-Ming
scheme or table, p. 817 - 825 (2011/10/02)
The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β- d-galactopyranosyl)- β- d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.
