98284-66-3Relevant academic research and scientific papers
PHENOL GLYCOSIDES AND THEIR USE IN THE TREATMENT OF UROLITHIASIS
-
Page/Page column 26; 27; 32; 33, (2017/01/26)
The present invention relates to novel derivatives of polyphenol glycoside or polyalcohols of formula (1), wherein R1, R2, R3 is selected from the group consisting of H, OH, C(O)R4, C(0) OR4, 0 (Gly H3)n, wherein n = 0 1, 2, 3, and R4 is selected from the group consisting of H, alkyl, and Gly is a mono- or disaccharide residue. The present invention also relates to novel derivatives of glycoside polyphenols or polyalcohols, as pharmaceutical composition comprising a novel polyphenol glycoside or polyalcohols and the use of novel polyphenol glycoside or polyalcohols for the treatment of urolithiasis.
Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs
Wang, Chao,Zhang, Tian-Tai,Du, Guan-Hua,Zhang, Dong-Ming
scheme or table, p. 817 - 825 (2011/10/02)
The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β- d-galactopyranosyl)- β- d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.
