1373758-33-8Relevant academic research and scientific papers
A facile preparation of various N-heterocycles using amides and olefins
Gratia, Synthia S.,Vigneau, Edward S.,Eltayeb, Sumiea,Patel, Kishan,Meyerhoefer, Terence J.,Kershaw, Sonia,Huang, Victor,De Castro, Michael
, p. 448 - 452 (2014)
We herein report a one pot approach for the synthesis of various nitrogen containing heterocycles including: oxazolines, thiazolines, and dihydro dioxazines via the addition of amides to olefins in the presence of N-iodosuccinimide (NIS) and propionitrile
Synthesis of 2,5-disubstituted oxazoles and oxazolines catalyzed by ruthenium(II) porphyrin and simple copper salts
Zhong, Chuan Long,Tang, Bo Yang,Yin, Ping,Chen, Yue,He, Ling
experimental part, p. 4271 - 4277 (2012/06/18)
A novel and moderate synthesis of 2,5-disubstituted oxazoles and oxazolines involving ruthenium(II) porphyrin-copper chloride catalyzed cyclization was developed. These reactions using readily available benzene carboxylic acids and phenylethenes or phenylacetylenes are performed under mild conditions. The reactions proceed in series, giving rise to the formation of an intermolecular C-N bond and an intramolecular C-O bond, which yield oxazole or oxazoline derivatives simultaneously.
