1373763-19-9Relevant academic research and scientific papers
Br?nsted acidic ionic liquids: Green, efficient and reusable catalyst for synthesis of fluorinated spiro [indole-thiazinones/thiazolidinones] as antihistamic agents
Arya, Kapil,Rawat, Diwan Singh,Dandia, Anshu,Sasai, Hiroaki
experimental part, p. 117 - 122 (2012/05/20)
Br?nsted acidic ionic liquid containing nitrogen-based organic cations 1-methylimidazolium and 1-butyl-3-methylimidazolium and inorganic anions such as BF4-, PF6- and PTSA - used as catalysts and reaction medium for synthesis of fluorinated spiro[3H-indole-3,2′-tetrahydro-1,3-thiazine]-2,4′(1H)-diones (4a-f), fluorinated spiro[3H-indole-3,2′-thiazolidine]-2,4′ (1H)-diones (5a-f) in 90-97% yield by one-pot environmentally benign microwave induced technique. Synthesized compounds have been evaluated for their ability to inhibit the contractions induced by histamine on guinea pig ileum. The measurement of pA2 values suggested that the reported compounds showed H1-antagonism.
