1373764-95-4

Upstream product

• 2845-89-8 1-chloro-3-methoxy-benzene 
• 5337-93-9 4'-methylpropiophenone 
• 1464149-60-7 (2,4,6-trimethylphenyl)(3’-methoxyphenyl)iodonium triflate 
• 188912-48-3 (Z)-trimethyl-(1-p-tolylprop-1-enyloxy)silane 
• 150-19-6 O-methylresorcine 
• 2749-93-1 1-methyl-4-(1-propyn-1-yl)benzene 
• 66107-33-3 3-methoxyphenyl triflate 

Relevant academic research and scientific papers

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.

Catalytic Alkyne Arylation Using Traceless Directing Groups

By using Pd0/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C?C bond formation.

N-heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed α-arylation of ketones with aryl chlorides

An easily available NHC-Pd(II)-Im (NHC=N-heterocyclic carbene, Im=1-methylimidazole) complex was found to be an efficient catalyst for the α-arylation reaction between ketones and aryl chlorides. Under the optimal conditions, all reactions proceeded smoot