1373769-40-4Relevant academic research and scientific papers
Asymmetric synthesis of functionalized chromans via a one-pot organocatalytic domino Michael-hemiacetalization or -lactonization and dehydration sequence
Enders, Dieter,Urbanietz, Gregor,Hahn, Robert,Raabe, Gerhard
, p. 773 - 782 (2012)
Starting from 2-(nitrovinyl)phenols and various cyclic dicarbonyl nucleophiles, a one-pot thiourea-catalyzed diastereo- and enantioselective synthesis of polyfunctionalized chroman derivatives via a domino Michael-hemiacetalization and dehydration sequence as well as via a domino Michael-lactonization reaction is reported. Cyclopenta[b]chromenes, tricyclic spirochromans, and tetrahydro-1H-xanthenes bearing a variety of functional groups can be synthesized in this way in good to excellent yields (56-91%) and with very good diastereo- (88-99%de) and enantioselectivities (83-99% ee). Georg Thieme Verlag Stuttgart · New York.
