1373822-40-2Relevant academic research and scientific papers
Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction
Chen, Xiaoqi,Kopecky, David J.,Mihalic, Jeff,Jeffries, Shawn,Min, Xiaoshan,Heath, Julie,Deignan, Jeff,Lai, Sujen,Fu, Zice,Guimaraes, Cristiano,Shen, Shanling,Li, Shyun,Johnstone, Sheree,Thibault, Stephen,Xu, Haoda,Cardozo, Mario,Shen, Wang,Walker, Nigel,Kayser, Frank,Wang, Zhulun
, p. 3837 - 3851 (2012/07/28)
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein synthesis by binding the 5′ terminal mRNA cap structure. We designed and synthesized a series of novel compounds that display pot
