1373929-29-3

Upstream product

• 1035815-57-6 4-(benzyloxy)-2-methyl-3-oxobutanoic acid 
• 214333-77-4 benzyl 4-(benzyloxy)-2-methyl-3-oxobutanoate 
• 67354-37-4 4-(benzyloxy)-3-oxobutanoic acid 
• 1373929-25-9 (2R,3R,4S)-3-benzyloxymethyl-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester 
• 1373929-23-7 (2R,5R,6R,7R)-1-aza-2-(tert-butyl)-6-hydroxy-6-(benzyloxymethyl)-5-methoxycarbonyl-7-methyl-3-oxa-8-oxobicyclo[3.3.0]octane 
• 1373929-15-7 (2R,5R,6R,7S)-1-aza-6-((benzyloxy)methyl)-2-(tert-butyl)-6-hydroxy-5-methoxycarbonyl-7-methyl-3-oxa-8-oxobicyclo[3.3.0]-octane 
• 1373929-12-4 (2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine 
• 1373929-04-4 (2R,5R,6R)-1-aza-2-(tert-butyl)-6-hydroxy-6-(benzyloxymethyl)-5-methoxycarbonyl-3-oxa-8-oxobicyclo[3.3.0]octane 
• 1373928-98-3 methyl (2R,4S)-3-(4-benzyloxy-3-oxobutanoyl)-2-t-butyl-oxazolidine-4-carboxylate 
• 61795-51-5 benzyl 4-(benzyloxy)-3-oxobutanoate 

Relevant academic research and scientific papers

Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin

Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data.