1373935-52-4Relevant academic research and scientific papers
Facile synthesis of nonsymmetrical heteroaryl-substituted triarylmethanes: Via the FeCl3·6H2O-catalyzed two-step Friedel-Crafts-type reaction
Ruengsangtongkul,Taprasert,Sirion,Jaratjaroonphong
, p. 8493 - 8502 (2016/09/28)
The FeCl3·6H2O-catalyzed three-component aza-Friedel-Crafts reaction of aromatic/heteroaromatic compounds, aromatic aldehydes and tert-butyl carbamate was reported. The subsequent Friedel-Crafts-type alkylation of the resulting tert-
Bi(OTf)3-Catalyzed One-Step Catalytic Synthesis of N-Boc or N-Cbz Protected α-Branched Amines
Jaratjaroonphong, Jaray,Tuengpanya, Surisa,Ruengsangtongkul, Sureeporn
, p. 559 - 567 (2015/08/11)
In this paper, N-Boc and N-Cbz protected α-branched amines are synthesized directly from commercially available aromatic/heteroaromatic compounds, aldehydes, and tert-butyl or benzyl carbamate bearing a variety of substituents. Bismuth(III) triflate is found to be a highly effective catalyst for this one-pot, three-component coupling reaction. In addition, the use of mild reaction conditions, low catalytic loading, easy removal of the N-protective group, and one-step synthesis under "open-flask" are advantages of the present procedure.
NIS-assisted aza-Friedel-Crafts reaction with α-carbamoysulfides as precursors of N-carbamoylimines
George, Nicolas,Bekkaye, Mathieu,Alix, Aurelien,Zhu, Jieping,Masson, Geraldine
supporting information, p. 3621 - 3625 (2014/04/03)
A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel-Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from α-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
Ruthenium porphyrin catalyzed friedel-crafts type reaction of arenes with imines
Terada, Takuma,Kurahashi, Takuya,Matsubara, Seijiro
, p. 2415 - 2419 (2012/11/13)
Cationic ruthenium porphyrin complex was found to be an efficient catalyst for the Friedel-Crafts type reaction of arenes with imines. The use of a structurally rigid tetradentate porphyrin as the equatorial ligand and weakly coordinating axial ligand is the key to bring out the catalytic reactivity of ruthenium for the reaction.
Iodine-catalyzed, one-pot, three-component aza-Friedel-Crafts reaction of electron-rich arenes with aldehyde/carbamate combinations
Jaratjaroonphong, Jaray,Krajangsri, Suppachai,Reutrakul, Vichai
experimental part, p. 2476 - 2479 (2012/06/01)
Iodine is shown to be an efficient catalyst for a one-step, three-component aza-Friedel-Crafts reaction of activated arenes or heteroarenes with benzyl or tert-butyl carbamates in combination with a wide variety of aldehydes in toluene under 'open-flask'
