137394-79-7Relevant academic research and scientific papers
Asymmetric synthesis of deuterated and fluorinated aromatic α,α-disubstituted amino acid derivatives
Hartmann, Caroline E.,Baumann, Thomas,Baechle, Michael,Braese, Stefan
scheme or table, p. 1341 - 1349 (2010/10/21)
We herein present organocatalytic approaches to synthesize fluorinated and deuterated α-substituted phenylglycine derivatives. Whereas the addition of diethyl azodicarboxylate to fluorinated α-substituted aldehydes furnishes chiral non-racemic compounds, the use of chloramine-T as a nitrogen source represents a rapid access to sulfamidated fluorinated amino acid precursors. Additionally, further functionalization was achieved through the palladium-catalyzed coupling of a p-bromosubstituted aldehyde with a range of fluorine or deuterium-containing boronic acids. Oxidation of the aldehyde function and cleavage of the protection group of the nitrogen give way to the free fluorinated unnatural amino acids.
Sulfamidation of 2-arylaldehydes and ketones with chloramine-T
Baumann, Thomas,Bachle, Michael,Brase, Stefan
, p. 3797 - 3800 (2007/10/03)
A series of aliphatic and aromatic carbonyl compounds has been transformed into the corresponding sulfamidated products by means of amine-catalyzed nitrene transfer of chloramine-T. Depending on the residues R, either α-sulfamidation in the case of aromat
