1374003-05-0

Upstream product

• 1346641-42-6 3,3,3-trichloro-2-methyl-2-propyl imidazole-1-carboxylate 
• 1374003-80-1 N-(2,2,2-trichloro-1,1-dimethyl-1-ethyloxycarbonyl)imidazolium tosylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 66270-36-8 2,2,2-trichloro-1,1-dimethylethoxychloroformate 

Downstream Products

• 1374003-14-1 (R)-1,1,1-trichloro-2-methylpropan-2-yl 2-(4-nitrophenyl)aziridine-1-carboxylate 

Relevant academic research and scientific papers

Double Functionalization of Styrenes by Cu-Mediated Assisted Tandem Catalysis

The double functionalization of styrenes through Cu-mediated assisted tandem catalysis was developed. The reaction was initiated by Cu-catalyzed aziridination and the subsequent nucleophilic ring-opening, which was triggered by the addition of (NH4)2S2O8 as an oxidant of Cu-catalyst to form a variety of C–C and C–X bonds. The expansion to three contiguous catalytic cycles led to the synthesis of functionalized indolines by one-pot operation.

Copper bis(oxazolines) as catalysts for stereoselective aziridination of styrenes with N-tosyloxycarbamates

A Cu(I)-catalyzed asymmetric aziridination of styrenes with a chiral N-tosyloxycarbamate has been developed. Double stereodifferentiation was observed and both the N-tosyloxycarbamate substituent and the bis(oxazoline) ligand have a significant effect on the yields and diastereoselectivities. The best results for the aziridination were obtained with electron-deficient styrenes. Subsequent ring-opening reactions of styrene-derived aziridines at the benzylic position were observed with various oxygen and nitrogen nucleophiles under Lewis acid catalysis affording the corresponding products with complete inversion of stereochemistry. The strategy was used to synthesize the β-blocker, (R)-nifenalol.