1374016-16-6Relevant articles and documents
NOVEL IODINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND USE THEREOF AS AMINATION AGENTS
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Page/Page column 78, (2012/12/13)
The iodine compounds of the present invention corresponds to those of formula (I), wherein R1, R1' and X have several meanings. These iodine compounds gives rise to the amination of several substrates without the need of catalysts, especially metal catalysts, and confer to the amination reaction the further advantage of being performed under mild conditions, which is of interest for industrial-scale production of nitrogenated compounds with pharmaceutical, biological or medicinal applications. Therefore, the iodine compounds of the invention are useful as amination agents. The invention also discloses several processes for the preparation of the iodine compounds of formula (I).
Iodine(III)-mediated intermolecular allylic amination under metal-free conditions
Souto, Jose A.,Zian, Debora,Muniz, Kilian
supporting information; experimental part, p. 7242 - 7245 (2012/06/16)
A new approach to direct intermolecular allylic amination has been developed using metal-free conditions at room temperature. The reaction employs a hypervalent iodine(III) reagent as an oxidant and bistosylimide as a nitrogen source. A series of different allylic aminations are presented with up to a 99% yield. Mechanistic studies including isotope labeling and Hammett correlation suggest that depending on the substrate structure two different mechanisms can be operating.
