1830-68-8

Basic information

• Product Name: Benzene, 1-(1-methylethenyl)-4-nitro-
• CAS NO: 1830-68-8
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.176
• Mol File: 1830-68-8.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1-methylethenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-methylethenyl)-4-nitro-(1830-68-8)
• EPA Substance Registry System: Benzene, 1-(1-methylethenyl)-4-nitro-(1830-68-8)

Safety Data

• Hazardous Substances Data: 1830-68-8(Hazardous Substances Data)

Upstream product

• 1817-47-6 4-nitrocumene 
• 50-00-0 formaldehyd 
• 100-12-9 4-ethylnitrobenzene 
• 3276-35-5 2-nitro-2-(4-nitrophenyl)propane 
• 2492-26-4 sodium 2-mercaptobenzothiazole 
• 40107-54-8 4-methyl-3H-thiazole-2-thione; sodium salt 
• 70951-50-7 α,α-dimethyl 4-nitrobenzylbromide 
• 14500-58-4 4-nitrocumyl chloride 
• 39980-20-6 dimethyl (4-nitrobenzyl)phosphonate 
• 591-27-5 m-Hydroxyaniline 
• 108-95-2 phenol 
• 636-98-6 p-nitrobenzene iodide 
• 13291-18-4 isopropenylmagnesium bromide 
• 1265920-51-1 N-[1-(4-nitrophenyl)ethylidene]-N'-(2,2,3-trimethylpenta-3,4-dienylidene)hydrazine 

Downstream Products

• 56077-92-0 peroxymethylene radical 
• 100-19-6 (4-nitrophenyl)ethanone 
• 301326-36-3 C₁₀H₉Br₂NO₂ 
• 1308661-35-9 1-[(4-methylphenyl)sulfonyl]-2-(4-nitrophenyl)propan-2-ol 
• 1334049-15-8 diethyl 2-hydroxy-2-(4-nitrophenyl)propylphosphonate 
• 1374016-16-6 4-methyl-N-(2-(4-nitrophenyl)allyl)-N-tosylbenzenesulfonamide 
• 75590-19-1 p-nitro-α-methylstyrene oxide 
• 56858-46-9 1-(4-nitrophenyl)-2-(toluene-4-sulfonyl)ethanone 

Relevant articles and documents

The kinetics and mechanism of the reaction of p-nitrocumyl bromide with nitrite ions in dimethyl sulfoxide. Evidence for a non-chain reaction giving a high nitro/nitrite ratio in the product

The reaction of p-nitrocumyl bromide (RBr) with sodium nitrite in [2H6]dimethyl sulfoxide gives none of the conventional evidence for an SRN1 chain reaction but the initial values of the [RNO2]/[RONO] ratio (2.5

A facile preparation of dialkyl phosphonate compounds from sterically hindered p-nitrocumyl halides through the S(RN)1 mechanism

p-Nitrobenzyl phosphonate anion with p-nitrocumyl halides gives a good yield of the coupling product dialkyl[(1,1-dimethyl-1,2-di-(p- nitrobenzyl)ethyl] phosphonates through the S(RN)1 mechanism. The reaction was greatly accelerated by sunlamp irradiation but inhibited by the radical scavenger (t-Bu)2NO..

METHOD FOR OXIDATIVE CLEAVAGE OF COMPOUNDS WITH UNSATURATED DOUBLE BOND

A method for oxidative cleavage of a compound with an unsaturated double bond is provided. The method includes the steps of: (A) providing a compound (I) with an unsaturated double bond, a trifluoromethyl-containing reagent, and a catalyst; wherein, the catalyst is represented by Formula (II): M(O)mL1yL2z??(II);wherein, M, L1, L2, m, y, z, R1, R2 and R3 are defined in the specification; and(B) mixing the compound with an unsaturated double bond and the trifluoromethyl-containing reagent to perform an oxidative cleavage of the compound with the unsaturated double bond by using the catalyst in air or under oxygen atmosphere condition to obtain a compound represented by Formula (III):

Method for oxidative cracking of compound containing unsaturated double bonds

The invention relates to a method for oxidative cracking of a compound containing unsaturated double bonds. The method comprises the following steps: (A) providing a compound (I) containing unsaturated double bonds, a trifluoromethyl-containing reagent and a catalyst, wherein the catalyst is shown as a formula (II): M(O)mL1yL2z (II), M, L1, L2, m, y, z, R1, R2 and R3 being defined in the specification; and (B) mixing the compound containing the unsaturated double bonds and the trifluoromethyl-containing reagent, and performing an oxidative cracking reaction on the compound containing the unsaturated double bonds in the presence of air or oxygen by using the catalyst to obtain a compound represented by formula (III),.

METHOD FOR OXIDATIVE CLEAVAGE OF COMPOUNDS WITH UNSATURATED DOUBLE BOND

A method for oxidative cleavage of a compound with an unsaturated double bond is provided. The method comprises the following step: (A) providing a compound (I) with an unsaturated double bond, a reagent with trifluoromethyl, and a catalyst; wherein the catalyst is represented by the following formula (II): M(O)mL1yL2z (II); wherein, M, L1, L2, m, y, z, R1, R2 and R3 are defined in the specification; and (B) mixing the compound with an unsaturated double bond and the reagent with a trifluoromethyl to perform an oxidation of the compound with the unsaturated double bond by using the catalyst at air or an oxygen condition to get a compound presented as formula (III):

Synthesis of N-Alkylpyridin-4-ones and Thiazolo[3,2- a]pyridin-5-ones through Pummerer-Type Reactions

N-Alkylated 4-pyridones were obtained through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride-activated sulfoxides and 4-fluoropyridine derivatives, followed by hydrolysis. On the other hand, triflic anhydride-activated benzyl 6-fluoro-2-pyridyl sulfoxide could react with alkenes or alkynes to afford thiazolo[3,2-a]pyridin-5-ones, via the pyridinium salt intermediates.

Palladium/Acid Relay Catalyzed Tandem Heck Coupling/6-Endo Cyclization between ortho-Halogenated Benzoates and Unactivated Terminal Alkenes for the Synthesis of 1-Isochromanones

We report a unique and expeditious route to synthesize 1-isochromanone derivatives through palladium catalyzed tandem Heck coupling/6-endo hydroacyloxylation cyclization between readily available ortho-halogenated benzoates and unactivated alkenes. Various 2-bromo or 2-iodo benzoates can be coupled efficiently with a broad range of alkenes to afford functionalized 1-isochromanones in high yields. Significantly, this cost-efficient and easy-to-handle synthetic methodology will have great prospect application in the synthetic and medicinal chemistry. (Figure presented.).

Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres

A geminal difluorination of alkenes based on I(I)/I(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally diverse styrenes (27 examples, up to 89% yield). Employing inexpensive p-TolI as the organocatalyst, turnover is enabled by Selectfluor-mediated oxidation to generate the ArIF2 species in situ. Extension to include α-substituted styrenes bearing fluorine-containing groups is disclosed and provides an expansive platform for the generation of fluorine-rich architectures.

Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines

The Crabtree's reagent catalyzes the isomerization of N-sulfonyl 2,2-disubstituted aziridines to allyl amines. The selectivity of allyl amine vs imine is very high (up to 99/1). The unprecedented isomerization takes place in mild conditions without activation of the catalyst by hydrogen. The mechanism has been studied computationally by DFT calculations; instead of the usual hydrogenation of COD, the catalytic species is formed by a loss of the pyridine ligand. Approaching of aziridine to this unsaturated species leads to a carbocation intermediate through a low energy barrier. A metal-mediated tautomerization involving sequentially γ-H elimination and N-H reductive elimination affords selectively the allyl amine. The readiness of the CγH bond to participate in the H elimination step accounts for the selectivity toward the allyl amine product.

METHODS OF PROMOTING BETA CELL PROLIFERATION

The present disclosure provides methods of promoting proliferation of a pancreatic cell. The methods are useful for the treatment of diabetes and other diseases characterized by impaired glucose tolerance.