1374030-91-7Relevant academic research and scientific papers
Concise enantioselective synthesis of duloxetine via direct catalytic asymmetric aldol reaction of thioamide
Suzuki, Yuta,Iwata, Mitsutaka,Yazaki, Ryo,Kumagai, Naoya,Shibasaki, Masakatsu
, p. 4496 - 4500 (2012)
Direct catalytic asymmetric aldol reaction of thioamide offers a new entry to the concise enantioselective synthesis of duloxetine. The direct aldol protocol was scalable (>20 g) to afford the aldol product in 92% ee after LiAlH4 reduction, and 84% of the chiral ligand was recovered after recrystallization. The following four steps of transformation delivered duloxetine.
