1374109-87-1

Basic information

• Product Name: C₂₀H₁₈FN₃O₆
• Synonyms: C₂₀H₁₈FN₃O₆
• CAS NO: 1374109-87-1
• Molecular Weight: 415.378
• Mol File: 1374109-87-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₈FN₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₈FN₃O₆(1374109-87-1)
• EPA Substance Registry System: C₂₀H₁₈FN₃O₆(1374109-87-1)

Safety Data

• Hazardous Substances Data: 1374109-87-1(Hazardous Substances Data)

Upstream product

• 29969-57-1 2-chloro-6-nitroquinoline 
• 1374109-86-0 C₁₇H₂₅BFNO₆ 
• 1374109-85-9 C₁₁H₁₃BrFNO₄ 
• 1374109-84-8 C₁₁H₁₂BrNO₄ 
• 1374109-83-7 C₁₁H₁₂BrNO₃ 
• 115-18-4 2-methyl-3-buten-2-ol 
• 321-23-3 4-bromo-2-fluoronitrobenzene 

Relevant articles and documents

TAU IMAGING PROBE

An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.