1374161-80-4

Basic information

• Product Name: (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methyl-2-((R)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methyl-2-((R)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1374161-80-4
• Molecular Weight: 462.705
• Mol File: 1374161-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methyl-2-((R)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methyl-2-((R)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester(1374161-80-4)
• EPA Substance Registry System: (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methyl-2-((R)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester(1374161-80-4)

Safety Data

• Hazardous Substances Data: 1374161-80-4(Hazardous Substances Data)

Upstream product

• 1374161-77-9 (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 114676-91-4 1-tert-butyl 2-methyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidine-1,2-dicarboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 165177-73-1 (2S,4R)-4-(tert-butyldimethylsilanyloxy)-2-methylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 1063998-64-0 (2S,4R)-4-Hydroxy-pyrrolidine-2-carbonyl chloride 

Downstream Products

• 1374161-82-6 (2S,4R)-4-hydroxy-2-methyl-2-((R)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1374161-84-8 (2S,4R)-4-hydroxy-2-methylpyrrolidine-2-carboxylic acid ((R)-1-phenylethyl)amide 

Relevant articles and documents

Structure-reactivity studies of simple 4-hydroxyprolinamide organocatalysts in the asymmetric Michael addition reaction of aldehydes to nitroolefins

A series of simple 4-hydroxyprolinamides was synthesised and they were found to act as organocatalysts for the asymmetric conjugate addition of aldehydes to nitroolefins in excellent yields (98%), with complete diastereoselectivity (99:1, syn:anti) and enantioselectivity (98% ee for syn). Furthermore, the use of low catalyst loadings (5mol%) and a low aldehyde molar excess (1.5equivalents) were achieved. Copyright