1374264-52-4

Basic information

• Product Name: 3-Amino-5-bromo-2-methylbenzoic acid
• Synonyms: 113860;Benzoic acid, 3-amino-5-bromo-2-methyl-
• CAS NO: 1374264-52-4
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.07
• Mol File: 1374264-52-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Amino-5-bromo-2-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-bromo-2-methylbenzoic acid(1374264-52-4)
• EPA Substance Registry System: 3-Amino-5-bromo-2-methylbenzoic acid(1374264-52-4)

Safety Data

• Hazardous Substances Data: 1374264-52-4(Hazardous Substances Data)

Upstream product

• 220514-28-3 5-bromo-2-methyl-3-nitrobenzoic acid methyl ester 
• 1000342-11-9 2-methyl-3-amino-5-bromobenzoic acid methyl ester 
• 107650-20-4 5-bromo-2-methyl-3-nitro-benzoic acid 

Relevant articles and documents

The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor

By targeting the unique Cys663 of EZH2, SKLB-0335 displays high paralog-selectivity on EZH2. Biochemical studies show that SKLB-0335 can covalently bind to EZH2 at its S-adenosylmethionine (SAM) pocket and inhibit H3K27Me3. SKLB-0335 could be an effective chemical probe with which to further investigate the specific biological functions of EZH2.

ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS

This invention relates to novel substituted benzamide according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.