1374429-86-3Relevant articles and documents
An Hsp90 modulator that exhibits a unique mechanistic profile
Ramsey, Deborah M.,McConnell, Jeanette R.,Alexander, Leslie D.,Tanaka, Kaishin W.,Vera, Chester M.,McAlpine, Shelli R.
, p. 3287 - 3290 (2012/06/29)
Described is the synthesis of two biotinylated derivatives of a cytotoxic macrocycle. Pull-down assays indicate that this macrocycle targets the N-middle domain of Hsp90. Untagged compound can effectively compete away tagged compound-Hsp90 protein complex
