1374433-35-8

Upstream product

• 1374578-16-1 (S)-[1-(benzyloxy)but-3-yn-2-yloxy](tert-butyl)dimethylsilane 
• 1374433-17-6 (S,E)-[1-(benzyloxy)-4-iodobut-3-en-2-yloxy](tert-butyl)dimethylsilane 
• 1374433-32-5 (2S,15S,E)-16-(benzyloxy)-15-(tert-butyldimethylsilyloxy)hexadec-13-en-11-yn-2-ol 
• 3452-09-3 1-nonyne 
• 78469-77-9 1-O-benzyl-2,3-O-isopropylidene-D-threitol 
• 85428-24-6 (S)-1-(benzyloxy)but-3-yn-2-ol 
• 1374433-25-6 (4R,5S)-4-(benzyloxymethyl)-5-(chloromethyl)-2,2-dimethyl-1,3-di-oxolane 
• 1374433-14-3 (S)-dodec-11-yn-2-ol 
• 140461-17-2 (S)-dodec-4-yn-2-ol 

Downstream Products

• 52461-05-9 (+)-aspicilin 
• 1374433-38-1 (S)-12-[(4R,5S)-5-{(R)-2-(benzyloxy)-1-(tert-butyldimethylsilyloxy)-ethyl}-2,2-dimethyl-1,3-dioxolan-4-yl]dodec-11-yn-2-ol 

Relevant academic research and scientific papers

Total synthesis of (+)-aspicilin by an alkyne-based approach and its biological evaluation

The stereoselective total synthesis of (+)-aspicilin is described. The pivotal step in this approach is the generation of an enyne intermediate by the coupling of an alkyne with vinyl iodide, which constructed the C6-C7 bond. Conversion of the enyne to th