85428-24-6Relevant articles and documents
Small Molecule Inhibitors of KRAS G12C Mutant
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Paragraph 0511-0512, (2021/04/30)
The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Rs
Synthesis and Modular Reactivity of Pyrazole 5-Trifluoroborates: Intermediates for the Preparation of Fully Functionalized Pyrazoles
Fricero, Prisca,Bialy, Laurent,Brown, Andrew W.,Czechtizky, Werngard,Méndez, María,Harrity, Joseph P. A.
, p. 1688 - 1696 (2017/02/10)
The regioselective condensation of hydrazines and ynone trifluoroborates provides access to a range of pyrazole 5-trifluoroborates. The stability of the borate unit allows chemoselective halogenation of the heteroaromatic ring, thereby delivering pyrazole scaffolds that allow orthogonal functionalization at C5 and C4. The modular reactivity of these intermediates is exemplified by cross-coupling reactions, enabling regiocontrolled synthesis of fully functionalized pyrazole derivatives.
Stereoselective total synthesis of oplopandiol, oploxyne A, and oploxyne B
Reddy, B.V. Subba,Nageshwar Rao,Kumaraswamy,Yadav
, p. 4590 - 4592 (2014/12/10)
A stereoselective total synthesis of oplopandiol, oploxyne A, and (-)-oploxyne B is described. The key reactions include Sharpless asymmetric epoxidation, d-proline catalyzed aminoxylation, Cadiot-Chodkiewicz cross-coupling reaction, m-CPBA induced substrate-controlled stereoselective epoxidation, and Lewis acid catalyzed stereo- and regioselective ring-opening of epoxide.
