1374457-20-1

Basic information

• Product Name: 3-bromo-5-hydroxy-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one
• Synonyms: 3-bromo-5-hydroxy-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one
• CAS NO: 1374457-20-1
• Molecular Weight: 352.184
• Mol File: 1374457-20-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-5-hydroxy-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-hydroxy-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one(1374457-20-1)
• EPA Substance Registry System: 3-bromo-5-hydroxy-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one(1374457-20-1)

Safety Data

• Hazardous Substances Data: 1374457-20-1(Hazardous Substances Data)

Upstream product

• 1395316-14-9 3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one 
• 1073353-55-5 pyrrolidin-1-yl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone 
• 14047-29-1 4-carboxyphenylboronic acid 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 

Relevant articles and documents

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1

Microsomal prostaglandin E2 synthase-1 (mPGES-1) has been recognized as novel, promising drug target for anti-inflammatory and anticancer drugs. mPGES-1 catalyzes the synthesis of the inducible prostaglandin E 2 in response to pro-inflammatory stimuli, rendering this enzyme extremely interesting in drug discovery process owing to the drastic reduction of the severe side effects typical for traditional non-steroidal anti-inflammatory drugs. In the course of our investigations focused on this topic, we identified two interesting molecules bearing the γ- hydroxybutenolide scaffold which potently inhibit the activity of mPGES-1. Notably, the lead compound 2c that inhibited mPGES-1 with IC50 = 0.9 μM, did not affect other related enzymes within the arachidonic acid cascade.