1374458-53-3Relevant academic research and scientific papers
Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives
Franco, Lucas Lopardi,de Almeida, Mauro Vieira,e Silva, Luiz Francisco Rocha,Vieira, Pedro Paulo Ribeiro,Pohlit, Adrian Martin,Valle, Marcelo Siqueira
, p. 790 - 797 (2012)
Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0μm≤IC50≤5.0μm) against blood forms of the human malaria parasite Plasmodium falciparum.
