13745-58-9

Usage

Uses

Used in Pharmaceutical Research:
2,4-Dimethyl-2H-pyrazole-3-carboxylic acid is used as a building block for the development of new drugs, leveraging its structural diversity and versatile reactivity to create compounds with potential antitumor, antiviral, and antimicrobial properties.
Used in Organic Synthesis:
DMPA is used as a key intermediate in the synthesis of various biologically active compounds and agrochemicals, contributing to the creation of innovative products across different industries.
Used in Drug Discovery:
2,4-Dimethyl-2H-pyrazole-3-carboxylic acid is utilized in drug discovery processes, where its unique structure and reactivity aid in the exploration and development of novel therapeutic agents with potential applications in medicine and healthcare.

Upstream product

• 82231-51-4 4-methyl-1H-pyrazole-3-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 6076-12-6 ethyl 4-methyl-1H-pyrazole-5-carboxylate 
• 68809-64-3 ethyl 1,4-dimethyl-1H-pyrazole-5-carboxylate 

Downstream Products

• 1005783-33-4 N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1,4-dimethyl-1H-pyrazole-5-carboxamide 
• 89202-85-7 N-Phenyl-1,4-dimethylpyrazole-5-carboxamide 

Relevant academic research and scientific papers

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

AMIDO COMPOUNDS AS AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF

The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.